Table 1 Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) (μg/mL) of carvacrol against four strains of Streptococcus pyogenes.

Drug	Strains of Streptococcus pyogenes
	ATCC 19615		ATCC 49399		Clinical isolate		Spy 1558
	MIC^a	MBC^b	MIC^a	MBC^b	MIC^a	MBC^b	MIC^a	MBC^b
Carvacrol	125	250	125	250	125	250	125	250
Penicillin G	0.008	0.016	0.008	0.016	0.008	0.016	0.008	0.016
Penicillin Vk	0.008	0.016	0.008	0.016	0.008	0.016	0.008	0.016
Clindamycin	0.031	0.063	0.031	0.063	0.031	0.063	0.250	0.500
Erythromycin	0.125	0.250	0.125	0.250	0.125	0.250	15.63	31.25

Data are representative of three independent experiments.
^aMinimum inhibitory concentration (MIC) was determined as the lowest concentration of tested compound that inhibited bacterial growth.
^bMinimum bactericidal concentration (MBC) was determined as the lowest concentration of tested compound that killed at least 99.9% of the initial inoculums.

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