Figure 4
CR6-interacting factor 1 (CRIF1) downregulation leads to decreased cell migration measured by scratch wound healing assay in normal fibroblasts (NFs) and keloid fibroblasts (KFs). (A) NFs were transfected with CRIF1 siRNA in a dose-dependent manner for 24 h, followed by wounding for 24 h. (B) KFs were transfected with CRIF1 siRNA in a dose-dependent manner for 24 h, followed by wounding for 24 h. Images were taken using a light microscope. Quantification of wound closure was performed using ImageJ software. All data are presented as means ± SD of three independent experiments. *P < 0.05 compared to siCON.
