Table 2 Neuropsychological tests, domains, functions and source of normal data.

From: Cognitive impairment without altered levels of cerebrospinal fluid biomarkers in patients with encephalitis caused by varicella-zoster virus: a pilot study

Cognitive domain

Neuropsychological test

Task and function

Specific variables analysed

References

Executive functions

Continuous performance test (CPT) II

Computerized target response task. Involves several aspects of sustained and selective attention, executive control, and reaction time

Omissions (failure to respond to target); commissions (response to non-target); reaction time (hit RT—average speed of correct responses)

32

Letter-number-sequencing

Recall a series of numbers in increasing order and letters in alphabetical order. Involves working memory, attention, executive control

Sum of correct responses

33

Trailmaking test B

Timed sequencing task, alternating letters and numbers. Visual scanning, psychomotor speed, cognitive flexibility

Time in seconds

34

Learning and memory

California verbal learning test (CVLT)

Word list learning (trial 1–5) and recall. Involves verbal episodic learning and memory

Total learning (sum of correct responses in trial 1–5); immediate recall; delayed recall

35

Brief visuospatial memory test revised (BVMT-R)

Timed spatial figure learning (trial 1–3) and recall. Involves spatial episodic learning and memory

Learning (trial 1–3); delayed recall

36

Speed and attention

Trailmaking test A

Timed sequencing task, numbers. Visual scanning and psychomotor speed

Time in seconds

34

Symbol digit modalities test

Timed substitution task using a reference key. Involves attention, psychomotor speed, perceptual speed, visual scanning

Sum of correct responses

37

Continuous performance test (CPT) II

See above

Reaction time (hit RT—average speed of correct responses)

32

Language

Boston naming test

Picture naming task. Involves confrontational word retrieval

Sum of correct responses

38

Category fluency (animals)

Timed word generation within a semantic category. Involves verbal fluency and executive control

Sum of correct responses

39

Visuospatial functions

Block tapping test

Tapping spatially separated blocks in predefined sequences of increasing length. Involves visuospatial working memory

Sum of correct responses

33

Silhouettes (VOSP battery)

Picture task, identifying objects and animals presented as silhouettes. Involves visuospatial perception

Sum of correct responses

40