Figure 5 | Scientific Reports

Figure 5

From: NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption

Figure 5

Decreased fatty acid uptake in adipose tissue from HFD-fed female NT-PGC-1α−/− mice. (A, B) Quantitative real time PCR analysis in inguinal and gonadal adipose tissue from female WT and NT-PGC-1α−/− mice fed HFD for 16 weeks (n = 12 per group). (C) Upregulation of fatty acid uptake genes by NT-PGC-1 in 3T3-L1 adipocytes (n = 6 per group). (D, E) Uptake of [14C]-palmitate in inguinal and gonadal adipose tissue from female WT and NT-PGC-1α−/− mice fed HFD for 8 weeks (n = 6 per group). (F, G) Expression of fatty acid uptake genes in muscle and liver from female WT and NT-PGC-1α−/− mice fed HFD for 16 weeks (n = 12 per group). All data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, #P < 0.0001 determined by Student’s t test.

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