Table 4 Prognostic value of clinical parameters.

Blood biomarkers	AUC	95% CI	Cut-off	Sensitivity	Specificity	P-value
INR	0.748	0.590–0.906	1.465	0.81	0.76	0.003*
NT-proBNP (ng/ml)	0.825	0.704–0.947	9086.59	0.70	0.80	0.000*
IL-6 (pg/ml)	0.785	0.647–0.923	2580.5	0.63	0.90	0.001*
Lactate (mmol/l)	0.776	0.633–0.918	3.75	0.63	0.84	0.001*
PT (s)	0.700	0.529–0.870	17.55	0.71	0.78	0.017*
APTT (s)	0.698	0.552–0.844	44.50	0.82	0.47	0.016*
SOFA scores	0.732	0.586–0.878	7.5	0.71	0.76	0.005*
APACHE II scores	0.850	0.758–0.942	27.5	0.94	0.69	0.000*
IL-6 + NT-proBNP	0.879	0.783–0.974	–	0.75	0.92	0.000*
IL-6 + INR + NT-proBNP	0.890	0.791–0.989	–	0.81	0.90	0.000*

AUC Area under the curve, CI confidence interval, IL-6 Interleukin 6, INR international normalized ratio, NT-proBNP N-terminal prohormone of brain natriuretic peptide, PT prothrombin time, APTT activated partial thrombin time, SOFA sequential organ failure assessment, APACHE II acute physiology and chronic health score II.
*Indicates a significant value, P < 0.05.

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