Table 1 Baseline descriptive demographic and clinical characteristics at PLCRC enrollment, stratified by tumor stage.
Baseline characteristics | Totala (n = 5722) | Stage I (n = 851) | Stage II (n = 1079) | Stage III (n = 1960) | Stage IV (n = 946) | Stage missingd (n = 886) |
|---|---|---|---|---|---|---|
Demographic and clinical characteristicsb | ||||||
Year of enrollment (n = 5722) | ||||||
2013–2016 | 1088 (19%) | 160 (19%) | 213 (20%) | 462 (24%) | 253 (27%) | 0 (0%) |
2017 | 1343 (24%) | 240 (28%) | 326 (33%) | 512 (26%) | 264 (28%) | 1 (< 1%) |
2018 | 2128 (37%) | 369 (43%) | 421 (39%) | 759 (39%) | 314 (33%) | 265 (30%) |
2019 (until August) | 1163 (20%) | 82 (10%) | 119 (11%) | 227 (12%) | 115 (12%) | 620 (70%) |
Age at enrollment (n = 5722) | 66.3 ± 10.6 | 67.7 ± 8.9 | 68.2 ± 10.3 | 65.7 ± 10.5 | 63.8 ± 10.9 | 66.7 ± 11.6 |
< 55 years | 720 (13%) | 49 (6%) | 95 (9%) | 263 (13%) | 196 (21%) | 117 (13%) |
55–64 years | 1652 (29%) | 240 (28%) | 290 (27%) | 582 (30%) | 286 (30%) | 254 (29%) |
65–74 years | 2040 (36%) | 372 (44%) | 386 (36%) | 708 (36%) | 308 (33%) | 266 (30%) |
75–84 years | 1117 (20%) | 165 (19%) | 249 (23%) | 365 (19%) | 140 (15%) | 198 (22%) |
≥ 85 years | 193 (3%) | 25 (3%) | 59 (6%) | 42 (2%) | 16 (2%) | 51 (6%) |
Days from diagnosis to enrollment (n = 5722) | 18 (1;131) | 14 (0;45) | 13 (-2;66) | 23 (3;156) | 188 (23;670) | 4 (-10;20) |
< 31 days | 3397 (59%) | 595 (70%) | 719 (67%) | 1087 (56%) | 269 (28%) | 727 (82%) |
31–90 days | 693 (12%) | 109 (13%) | 112 (10%) | 255 (13%) | 106 (11%) | 111 (13%) |
91–365 days | 637 (11%) | 61 (7%) | 79 (7%) | 239 (12%) | 211 (22%) | 47 (5%) |
> 365 days | 995 (17%) | 86 (10%) | 169 (16%) | 379 (19%) | 360 (38%) | 1 (< 1%) |
Sex (n = 5722) | ||||||
Male | 3526 (62%) | 532 (63%) | 685 (64%) | 1196 (61%) | 583 (62%) | 530 (60%) |
Female | 2196 (38%) | 319 (38%) | 394 (36%) | 764 (39%) | 363 (38%) | 356 (40%) |
Primary tumor location (n = 5722) | ||||||
Rectum (C19.9, C20.9) | 2231 (39%) | 321 (38%) | 347 (32%) | 1023 (52%) | 364 (38%) | 176 (20%) |
Colon (C18.0–18.9) | 3491 (61%) | 530 (62%) | 732 (68%) | 937 (48%) | 582 (62%) | 710 (80%) |
Right colon (C18.0–18.4) | 1403 (40%) | 254 (48%) | 410 (56%) | 432 (46%) | 253 (44%) | 54 (8%) |
Left colon (C18.5–18.7) | 1564 (45%) | 270 (51%) | 309 (42%) | 489 (52%) | 315 (54%) | 181 (25%) |
Colon unspecified (C18.8–18.9) | 524 (15%) | 6 (1%) | 13 (2%) | 16 (2%) | 14 (2%) | 475 (67%) |
Location synchronous metastases (n = 5722) | ||||||
Liver | 746 (13%) | 746 (79%) | ||||
Lung | 212 (4%) | 212 (22%) | ||||
Peritoneal | 163 (3%) | 163 (17%) | ||||
Molecular diagnostics (n = 570–2600, missing 55–90%) | ||||||
RAS mutation status determined | 596 (10%) | 9 (1%) | 30 (3%) | 119 (6%) | 438 (46%) | 0 (0%) |
BRAF mutation status determined | 570 (10%) | 14 (2%) | 48 (4%) | 121 (6%) | 387 (41%) | 0 (0%) |
Microsatellite instability (MSI) determined | 2600 (45%) | 436 (51%) | 582 (54%) | 1097 (56%) | 483 (51%) | 2 (< 1%) |
BMI at enrollment, kg/m2 (n = 3108, missing 46%)c | 26.3 ± 4.5 | 27.1 ± 4.6 | 26.3 ± 4.6 | 26.1 ± 4.2 | 25.8 ± 5.0 | 26.2 ± 4.3 |
Underweight (< 18.5) | 37 (1%) | 2 (< 1%) | 7 (1%) | 11 (1%) | 7 (1%) | 10 (2%) |
Normal weight (18.5–25) | 1313 (42%) | 170 (37%) | 198 (39%) | 466 (43%) | 261 (48%) | 218 (41%) |
Overweight (25–30) | 1254 (40%) | 185 (40%) | 214 (43%) | 435 (40%) | 199 (37%) | 221 (42%) |
Obese (> 30) | 504 (16%) | 101 (22%) | 83 (17%) | 165 (15%) | 74 (14%) | 81 (15%) |
Past 12 months treated for chronic disease, at enrollment (n = 2986, missing 48%)c | ||||||
Cardiac disease or stroke | 313 (11%) | 59 (13%) | 42 (9%) | 114 (11%) | 44 (9%) | 54 (11%) |
Diabetes | 290 (10%) | 38 (9%) | 58 (12%) | 117 (11%) | 27 (5%) | 50 (10%) |
Liver disease | 184 (6%) | 11 (3%) | 18 (4%) | 35 (3%) | 112 (22%) | 8 (2%) |
Kidney disease | 38 (1%) | 5 (1%) | 6 (1%) | 13 (1%) | 7 (1%) | 7 (1%) |
Smoking status at enrollment (n = 3140, missing 45%)c | ||||||
Current | 231 (7%) | 23 (5%) | 54 (11%) | 74 (7%) | 46 (8%) | 34 (6%) |
Former | 1840 (59%) | 293 (63%) | 286 (56%) | 646 (59%) | 298 (55%) | 317 (59%) |
Never | 1069 (34%) | 149 (32%) | 168 (33%) | 368 (34%) | 200 (37%) | 184 (34%) |
Past month average alcohol consumption at enrollment (n = 3111, missing 46%)c | ||||||
0 units per day | 1167 (38%) | 134 (29%) | 165 (33%) | 403 (37%) | 259 (48%) | 206 (39%) |
0–1 units per day | 1223 (39%) | 195 (42%) | 211 (42%) | 400 (37%) | 196 (36%) | 221 (42%) |
1–2 units per day | 464 (15%) | 82 (18%) | 75 (15%) | 182 (17%) | 58 (11%) | 67 (13%) |
> 2 units per day | 257 (8%) | 50 (11%) | 52 (10%) | 94 (9%) | 26 (5%) | 35 (7%) |
Living situation at enrollment (n = 3144, missing 45%)c | ||||||
Living alone | 530 (17%) | 74 (15%) | 87 (17%) | 183 (17%) | 90 (17%) | 96 (18%) |
Living with partner, without children | 1965 (63%) | 324 (70%) | 322 (63%) | 679 (62%) | 313 (57%) | 327 (61%) |
Living with partner and children | 537 (17%) | 51 (11%) | 82 (16%) | 189 (17%) | 120 (22%) | 95 (18%) |
Living alone with children | 69 (2%) | 8 (2%) | 12 (2%) | 26 (2%) | 12 (2%) | 11 (2%) |
Other | 43 (1%) | 8 (2%) | 5 (1%) | 13 (1%) | 11 (2%) | 6 (1%) |
Educational level (n = 3108, missing 46%)c | ||||||
≤ High school | 1206 (39%) | 201 (44%) | 194 (39%) | 401 (37%) | 192 (36%) | 218 (41%) |
Trade / college / other non-university | 1548 (50%) | 212 (46%) | 256 (51%) | 539 (50%) | 278 (51%) | 263 (49%) |
University | 354 (11%) | 45 (10%) | 53 (10%) | 135 (13%) | 70 (13%) | 51 (10%) |
