Table 5 Univariate and multivariate analyses of variables associated with severe drug-induced liver injury.
Variables | Level 0–2 (N = 128) | Level ≥ 3 (N = 36) | P# | AOR (95% CI)* | P** |
|---|---|---|---|---|---|
Sex | 0.157 | – | – | ||
Female, N(%) | 100 (78.1) | 24 (66.7) | |||
Male, N(%) | 28 (21.9) | 12 (33.3) | |||
Age | 0.353 | – | – | ||
< 60 | 108 (84.4) | 28 (77.8) | |||
≥ 60 | 20 (15.6) | 8 (22.2) | |||
Smoking | 0.355 | – | – | ||
No, N(%) | 111 (86.7) | 29 (80.6) | |||
Yes, N(%) | 17 (13.3) | 7 (19.4) | |||
Drinking | 0.017 | 4.938 (1.088–22.412) | 0.039 | ||
No, N(%) | 117 (91.4) | 27 (75.0) | |||
Yes, N(%) | 11 (8.6) | 9 (25.0) | |||
Hypersensitivity history | 0.096 | – | – | ||
No, N(%) | 102 (79.7) | 33 (91.7) | |||
Yes, N(%) | 26 (20.3) | 3 (8.3) | |||
Diabetes | 0.737 | – | – | ||
No, N(%) | 116 (90.6) | 34 (94.4) | |||
Yes, N(%) | 12 (9.4) | 2 (5.6) | |||
History of liver disease | 0.524 | – | – | ||
No, N(%) | 99 (77.3) | 26 (72.2) | |||
Yes, N(%) | 29 (22.7) | 10 (27.8) | |||
Dyslipidemia | 0.006 | 3.926 (1.282–12.026) | 0.017 | ||
No, N(%) | 89 (69.5) | 16 (44.4) | |||
Yes, N(%) | 39 (30.5) | 20 (55.6) | |||
INR | 0.180 | ||||
< 1.0 | 73 (57.0) | 16 (44.4) | |||
≧ 1.0 | 55 (43.0) | 20 (55.6) | |||
TBA | 14.75 (7.40, 56.95) | 185.60 (132.75, 271.85) | < 0.001 | 1.014 (1.009–1.020) | < 0.001 |
RDW | 13.75 (12.80, 14.80) | 16.65 (14.95, 19.70) | < 0.001 | 1.582 (1.261–1.986) | < 0.001 |
RPR | 0.07 (0.05, 0.09) | 0.07 (0.06, 0.09) | 0.617 | ||
RLR | 7.61 (6.10, 10.72) | 10.68 (8.44, 17.97) | < 0.001 | ||
AAR | 0.71 (0.50, 0.96) | 0.91 (0.69, 1.15) | 0.015 | ||
