Table 1 Number of differentially expressed (DE) genes (FDR < 0.05) in response to LPS on the autosomes and the X chromosome.

From: Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes

Category of genes

Autosomal

X-linked

Male-specific DE

632

23

Female-specific DE

585

31

Sex-specific

1217

54

DE in both sexes (FDR < 0.05)

8549

237

DE in both sexes (0.05 > FDR > 0.20)

1036

30

Neither DE (FDR > 0.20)

1673

72

Not specific

11,258

339

Sex-specific

1217

54

Not specific

11,258

339

Total

12,475

393

  1. DE genes considered sex-specific were significant at FDR < 0.05 in the primary sex and not significant at FDR < 0.20 in the opposite sex. There was an enrichment of sex-specific responses to LPS among X-linked genes (54/393, 13.7%) compared to autosomal genes (1217/12,475, 9.8%) (Fisher’s Exact Test P = 0.01).
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