Table 6 Time course for cytokine levels in patients with 7 or 13 high-risk HPV genotypes before surgery, but none after surgery.
Cytokines | Seven high-risk HPV genotypes in Japan (N = 13) | Thirteen high-risk HPV genotypes worldwide (N = 16) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of samples within detectable limits | Rate of specimens within detectable limits (%) | Cytokine level (pg/ml) mean | Adjustment of weighted volume (ng/mg) mean | Wilcoxon signed-rank test p value | No. of samples within detectable limits | Rate of specimens within detectable limits (%) | Cytokine level (pg/ml) mean | Adjustment of weighted volume (ng/mg) mean | Wilcoxon signed-rank test p value | |||
Before surgery | After surgery | Before surgery | After surgery | |||||||||
IL-1α | 26/26 | 100.0 | 1014.4 | 6,676.8 | 7,086.9 | 0.382 | 32/32 | 100.0 | 956.9 | 6,329.7 | 6,906.2 | 0.255 |
IL-1β | 26/26 | 100.0 | 2,485.3 | 19,260.6 | 17,985.8 | 0.600 | 32/32 | 100.0 | 2,154.4 | 16,937.5 | 15,441.4 | 0.362 |
IL-6 | 26/26 | 100.0 | 590.5 | 3,994.8 | 3,802.7 | 0.917 | 32/32 | 100.0 | 550.6 | 3,996.4 | 3,426.3 | 0.501 |
IFN-γ | 7/26 | 26.9 | 0.9 | 0.7 | 18.7 | 0.463 | 8/32 | 25.0 | 1.3 | 10.9 | 15.2 | 0.866 |
TNF-α | 20/26 | 76.9 | 50.7 | 344.2 | 328.1 | 0.286 | 25/32 | 78.1 | 46.1 | 335.9 | 283.0 | 0.124 |
GM-CSF | 2/26 | 7.7 | 0.1 | 0.9 | 0 | 0.180 | 3/32 | 9.4 | 0.1 | 1.1 | 0 | 0.109 |
G-CSF | 26/26 | 100.0 | 448.6 | 2,738.0 | 3,127.4 | 0.552 | 32/32 | 100.0 | 467.2 | 3,099.2 | 3,253.6 | 0.836 |
IL-10 | 20/26 | 76.9 | 20.3 | 61.8 | 173.0 | 0.929 | 24/32 | 75.0 | 18.5 | 75.2 | 148.8 | 0.551 |
IL-8 | 26/26 | 100.0 | 34,495.0 | 240,894.6 | 309,049.1 | 0.552 | 32/32 | 100.0 | 32,249.8 | 227,265.3 | 289,580.8 | 0.679 |
IL-17A | 3/26 | 11.5 | 1.3 | 13.0 | 0 | 0.109 | 3/32 | 9.4 | 1.0 | 10.6 | 0 | 0.109 |
MCP-1 | 26/26 | 100.0 | 369.7 | 2,278.0 | 2,564.7 | 0.463 | 32/32 | 100.0 | 422.9 | 3,104.6 | 2,517.1 | 0.179 |
MIP-1α | 26/26 | 100.0 | 148.9 | 801.9 | 1,413.0 | 0.600 | 32/32 | 100.0 | 144.0 | 907.5 | 1,288.2 | 0.959 |
RANTES | 24/26 | 92.3 | 45.6 | 253.7 | 398.6 | 0.279 | 29/32 | 90.6 | 76.9 | 296.4 | 863.6 | 0.326 |
Eotaxin | 7/26 | 26.9 | 1.6 | 19.4 | 0.2 | 0.028* | 7/32 | 21.9 | 1.3 | 15.8 | 0.2 | 0.028* |
