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Schematic of experimental procedures. (a) Optimization of MP2RAGE for T1 mapping of in vivo mouse brain at 9.4 T (see Supplemental Figs. S1–S6 and Fig. 2). (b) Optimization of image co-registration (see Figs. 3, 4, 5). (c) In vivo detection of ESIONPs in R1 (= 1/T1) map (see Figs. 6, 7, 8).