Figure 3

Forest plot of the joint effect of E + P use with risk behavioral factors and genotypes on breast cancer risk overall and in subgroups (A BMI < 30 and WHR ≤ 0.85; B MET ≥ 10 and SFA ≥ 9). The plot shows the independent and combined effect of risk behaviors and genotypes on breast cancer risk, jointly testing with E + P use, presented as the 95% CIs (indicated with red lines) and the estimates (proportional to the size of the blue squares). BMI, body mass index; CI, confidence interval; E + P, E + P, exogenous estrogen + progestin; HR, hazard ratio; MET, metabolic equivalent; SFA, saturated fatty acids; WHR, waist-to-hip ratio. * The combined number of risk genotypes and behavioral factors was based on risk genotypes defined as 0 (low risk: none or < total number of risk alleles) and 1 (high risk: combined all risk alleles) and based on behavioral factors defined as 0 (low risk: null risk behavior) and 1 (high risk: 1 or more risk behaviors). The ultimate number of risk genotypes combined with behavioral factors was defined as 0 (low risk for genotypes and behaviors), 1 (either high risk for genotypes or behaviors), and 2 (both high risk for genotypes and behaviors). ** The number of behavioral factors was defined as 0 (null risk behavior) vs. 1 (1 risk behavior) vs. 2 (2 or more risk behaviors).