Figure 5
Effects of AT1a receptor loss on prevention of AKI to CKD transition at 14 and 28 days postischemia. (a) IR kidney weight-to-body weight ratio shown as the fold-increase or fold-decrease compared with that of sham at 14 and 28 days postischemia. (b) Cross-sectional area of the IR kidney cut in transverse plane at the hilum of the kidney at 14 and 28 days postischemia, which was evaluated as the fold-increase or fold-decrease compared with that of the sham. (c,e,g,i) Immunohistochemical staining of F4/80 (c), type I collagen (e), type III collagen (g), and aquaporin-1 (i) in the IR kidneys at 14 days postischemia. (d,f,h,j) Quantification of the positively stained areas of F4/80 (d), type I collagen (f), type III collagen (h), and aquaporin-1 (j) in the IR kidneys at 14 days postischemia. The graphs show the fold-increase or -decease in each positively stained area in the IR kidney compared with that of the sham. Original magnification, × 100. Values are means ± SE. *P < 0.05 vs. AT1a+/+ mice on the same day.
