Figure 3
From: ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury
Effect of AR13503 intravitreal injection on axonal retraction of photoreceptors 2 h after retinal detachment. (A) 0.5 μM AR13503 treatment. There was a 40.2% decrease between the treated (AD) and the untreated (BD) detached areas (n = 3 animals, *p < 0.0001, using 120–180 images/animal, + /− SD). (B) 0.75 μM AR13503 treatment. Retraction was reduced by 21.6% in the treated detached area (AD) compared to the untreated detached area (BD) (n = 3 animals, p = 0.48, using 120–180 images/animal, + /− SD). (C) 1.5 μM AR13503 treatment. There was a 13.5% decrease in axonal retraction in the treated detached area (n = 4 animals, p = 0.43 using 120–180 images/animal, + /− SD). Only the 0.5 μM AR13503 dose showed a significant reduction in retraction. BC, AC, attached areas of the untreated and treated retina.
