Figure 5
From: ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury
Electrophysiological results 2 days after retinal detachment of eyes with spontaneous retinal reattachment. (A) Position of pig in the Ganzfeld stimulator. (B) There was a 48.6% difference in amplitude recovery between the AR13503-treated eyes, subretinal injection of 0.5 μM, compared to the eyes that received BSS alone (paired t-test, n = 5 animals, *p = 0.017, + /- SD). (C,D) Representative waveforms of rod-specific scotopic responses (0.01 cd s m-2). Red lines, untreated eye; blue lines, AR1303-treated eye. Solid line, preoperative response; dashed line, postoperative response. (C) At 2 days in the treated eye (blue solid and dashed lines) the evoked responses recovered to the baseline levels. However, in the untreated eye (red solid and dashed line) the response was lower than the recorded preoperative responses. (D) Representative waveform showing supernormal (higher than baseline) response recorded from treated eye (blue dashed line) at 2 days.
