Figure 1
Overall flow of the static and dynamic network reconfiguration during creative thinking task. (A) Static reconfiguration. The Blood oxygen level dependent (BOLD) time series signal was extracted from each of the 32 regions of interests (ROIs). The z-scored Pearson correlation coefficients for 32 ROIs were calculated and a statistical threshold of p < 0.05, false discovery rate (FDR)-correction was applied to obtain the estimated correlation map. A single adjacency matrix was estimated and a community detection algorithm was applied to identify communities for the whole brain flexibility over the entire scan duration. (B) Dynamic reconfiguration. The Blood oxygen level dependent (BOLD) time series signal was extracted from each of the 32 regions of interests (ROIs). An overlapping sliding window (length W) was used and time ordered functional connectivity matrices were estimated over these windows for all the ROIs using z-scored Pearson correlation. The estimated correlation maps Wn (n is number of windows) were statistically thresholded with p < 0.05 (FDR correction). A community detection algorithm was applied to all these matrices to detect communities across the windows.
