Table 1 Inclusion and exclusion criteria.

From: Comparing efficacy of intraarticular single crosslinked Hyaluronan (HYAJOINT Plus) and platelet-rich plasma (PRP) versus PRP alone for treating knee osteoarthritis

Inclusion criteria

Aged 20–75 years

Symptomatic knee OA ≥ 6 months despite conservative treatment such as oral analgesics, NSAIDs and/or physical therapy

Kellgren-Lawrence grades 2 knee OA on radiographs taken within the previous 6 months

Average pain at walking ≥ 30 mm on a 100-mm visual analog scale (VAS)

Radiological evidence of bilateral knee OA was accepted if global pain VAS in the contralateral knee < 30 mm

Exclusion criteria

Previous orthopedic surgery on the spine or lower limbs

Disabling OA of either hip or foot

Knee instability, apparent joint effusion or marked valgus/varus deformity

Known allergy to hyaluronan products

Women ascertained or suspected pregnancy or lactating

Intraarticular injections into the knee in the past 6 months

Any specific medical conditions (rheumatoid arthritis, active infections, severe cardiovascular diseases, autoimmune diseases, hemiparesis, neoplasm, etc.) that would interfere with the assessments

  1. OA osteoarthritis, NSAID nonsteroidal anti-inflammatory drugs, VAS visual analog scale.
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