Figure 7
Efferent-mediated fast excitation is selectively blocked by the nicotinic ACh receptor antagonist DHβE. (a,b) Average response histograms from an irregularly- and regularly-discharging afferent during ipsilateral stimulation, respectively, before (gray, Cntl) and after serial administration of DHβE (black, 1.4 mg/kg) and scopolamine (red, SCP, 1 mg/kg). Binning in panels (a,b) is 500 ms. (c,d) Values of mean peak fast (FastR) and slow excitation (SlowR) for ten units before and after DHβE. The range and mean doses were 1.4–5 mg/kg and 3.5 mg/kg, respectively. (e) Values of mean background discharge rates for 13 individual units before and after DHβE application. Examples shown in panel (a,b) appear as solid lines in panels (c–e). Indicated p value from comparisons made using a paired t test.
