Table 4 Uni- and multi-variable logistic regression analysis for risk factors in early and systemic recurrence.

From: Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma

Variable

Uni-variable

Multi-variable

OR*

95% CI

P-value†

OR1

95% CI

P-value†

Risk factors for the early recurrence

ASA

 < 3

1.000 (reference)

0.518

   

 ≥ 3

2.286

0.187–27.994

    

Neoadjuvant chemotherapy

 No

1.000 (reference)

0.698

   

 Yes

1.354

0.293–6.261

    

Adjuvant therapy

 No

1.000 (reference)

0.176

   

 Yes

4.923

0.489–49.611

    

CA 19–9(U/mL)

< 37

1.000 (reference)

0.737

   

≥ 37

1.266

0.329–4.867

    

CTCs

 Negative

1.000 (reference)

0.038

1.000 (reference)

0.027

 Positive

5.250

1.093–25.211

 

8.770

1.275–60.346

 

R0 resection‡

 Yes

1.000 (reference)

0.051

   

 No

3.046

0.998 ~ 9.300

    

Differentiation

 Well/moderate

1.000 (reference)

0.034

   

 Poor

11.200

1.193–105.132

    

Perineural invasion

 No

1.000 (reference)

0.518

   

 Yes

2.308

0.187–27.994

    

LVi

 No

1.000 (reference)

0.020

1.000 (reference)

0.027

 Yes

5.958

1.332 ~ 26.662

 

8.165

1.277 ~ 52.225

 

LN metastasis

 < 2

1.000 (reference)

0.034

   

 ≥ 2

6.667

1.151–38.598

    

Risk factors for the systemic recurrence

ASA

 < 3

1.000 (reference)

0.992

   

 ≥ 3

0.989

0.128 ~ 7.628

    

Neoadjuvant chemotherapy

 No

1.000 (reference)

0.573

   

 Yes

1.398

0.437–4.478

    

Adjuvant therapy

 No

1.000 (reference)

0.262

   

 Yes

28.117

0.083 ~ 66.339

    

CA 19-9 (U/mL)

 < 37

1.000 (reference)

0.718

   

 ≥ 37

0.824

0.289–2.354

    

CTCs

 Negative

1.000 (reference)

0.020

1.000 (reference)

0.033

 Positive

6.000

1.319–27.287

 

5.600

1.146–27.370

 

R0 resection‡

 Yes

1.000 (reference)

0.044

   

 No

10.556

1.070–104.114

    

Differentiation

 Well/moderate

1.000 (reference)

0.164

   

 Poor

1.470

0.854–2.530

    

Perineural invasion

 No

1.000 (reference)

0.665

   

 Yes

0.753

0.209–2.714

    

Lymphovascular invasion

 No

1.000 (reference)

0.159

   

 Yes

2.150

0.742–6.234

    

LN metastasis

 < 2

1.000 (reference)

0.625

   

 ≥ 2

1.707

0.200–14.576

    
  1. ASA classification American Society of Anesthesiologists physical status classification, CA 19-9 Carbohydrate antigen 19–9, CTCs circulating tumour cells, LN lymph node, CI confidence interval.
  2. *Odds ratios estimated using logistic regression analysis excluding possible confounding variables.
  3. †The p values were calculated using the logistic regression analysis.
  4. ‡R0 was defined as a distance of the tumour from the resection margin < 1 mm.
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