Table 1 Minimum inhibitory concentration (MIC) of drugs and the results of cytotoxicity studies.

From: Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Drugs

Mtb H37Rv strain

Mtb H37Rv strain (freshly passaged from guinea pig)

Cytotoxicityb

1 µg/mL

0.5 µg/mL

1 µg/mL

0.5 µg/mL

RIF

(Inhibited)

Scantya

(Inhibited)

Scantya

87 µg/mL

Phenazine(4)

(No Inhibition)

(No Inhibition)

(No Inhibition)

(No Inhibition)

RPZ (5)

(Inhibited)

(Inhibited)

(Inhibited)

Scantya

96 µg/mL

  1. aAble to see the growth of very few countable colonies.
  2. b(IC50 on human monocytic cell line THP-1).