Table 4 Univariate and multivariate Cox analysis of SPMs patients after PCa in the training and validation set.

From: Clinical characteristics and overall survival nomogram of second primary malignancies after prostate cancer, a SEER population-based study

Characteristics

Univariate analysis

Multivariate analysis

HR

CI95

p

HR

CI95

p

Site of SPM

  

< 0.001

  

< 0.001

Skin

Reference

Reference

Bronchus and lung

8.385

6.294–11.171

0.000

1.952

0.995–3.831

0.052

Renal

1.973

1.313–2.964

0.001

1.240

0.401–3.828

0.709

Liver

9.024

6.308–12.909

0.000

7.265

2.834–18.623

0.000

Thyroid gland

1.008

0.543–1.871

0.979

0.595

0.242–1.463

0.258

Others

2.671

1.990–3.585

0.000

0.978

0.513–1.866

0.947

Histology of SPM

 

< 0.001

  

0.002

Squamous cell neoplasms

Reference

Reference

Melanomas

0.199

0.147–0.269

0.000

0.549

0.278–1.085

0.085

Papillomas

0.292

0.186–0.458

0.000

0.921

0.412–2.058

0.841

Hepatocellular carcinoma

1.742

1.277–2.375

0.000

0.576

0.268–1.242

0.159

Adenocarcinomas

0.553

0.362–0.845

0.006

1.072

0.382–3.011

0.895

Others

0.815

0.666–0.997

0.047

1.364

1.084–1.717

0.008

Age

  

< 0.001

  

< 0.001

<= 60

Reference

Reference

61–70

1.211

0.885–1.657

0.231

1.130

0.818–1.561

0.458

71–80

1.861

1.373–2.521

0.000

1.692

1.224–2.340

0.001

> 80

2.465

1.734–3.504

0.000

2.354

1.619–3.424

0.000

Race

  

< 0.001

  

0.638

White

Reference

Reference

Black

1.605

1.287–2.001

0.000

1.040

0.821–1.317

0.747

Other

1.003

0.640–1.571

0.991

0.817

0.515–1.297

0.392

Stage_T

  

< 0.001

  

< 0.001

T1

Reference

Reference

Ta

1.381

0.873–2.186

0.167

1.443

0.878–2.372

0.148

T2

2.108

1.665–2.669

0.000

1.334

1.034–1.721

0.026

T3

2.930

2.309–3.719

0.000

1.626

1.242–2.127

0.000

T4

3.825

2.952–4.956

0.000

1.871

1.386–2.526

0.000

Stage_N

  

< 0.001

  

< 0.001

N0

Reference

Reference

N1

2.710

2.128–3.450

0.000

2.028

1.552–2.65

0.000

N2

3.516

2.838–4.357

0.000

1.493

1.152–1.934

0.002

N3

4.299

2.913–6.346

0.000

1.739

1.128–2.679

0.012

Stage_M

  

< 0.001

  

< 0.001

M0

Reference

Reference

M1

7.664

6.305–9.315

0.000

2.893

2.292–3.651

0.000

LNR

  

< 0.001

  

0.088

No

Reference

Reference

Yes

0.600

0.474–0.760

0.000

0.757

0.555–1.033

0.079

SPM surgical history

  

< 0.001

  

< 0.001

Yes

Reference

Reference

No

0.198

0.165–0.236

0.000

0.597

0.452–0.790

0.000

Histology of PCa

 

0.134

   

Other

Reference

Reference

Adenocarcinomas

0.538

0.240–1.203

0.131

   

PCa surgical history

  

< 0.001

  

0.450

Yes

Reference

Reference

No

0.600

0.495–0.726

0.000

0.930

0.751–1.151

0.503

PCa Stage

  

< 0.001

  

< 0.001

I

Reference

Reference

II

1.143

0.934–1.399

0.193

1.046

0.85–1.288

0.668

III

0.745

0.512–1.086

0.126

0.856

0.571–1.281

0.449

IV

2.411

1.704–3.410

0.000

2.419

1.684–3.476

0.000

Marital status

 

< 0.001

  

0.038

Married

Reference

Reference

Previously married

1.391

1.141–1.696

0.001

1.120

0.914–1.372

0.275

Never married

1.477

1.126–1.939

0.005

1.469

1.104–1.955

0.008

  1. Abbreviations: SPM: second primary malignancy; PCa: prostate cancer, LNR: lymph node removed.
Back to article page