Figure 1 | Scientific Reports

Figure 1

From: Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery

Figure 1

(a) A scheme showing a two-step hydrogel synthesis process involving the introduction of tyramine for positive-charge tuning and crosslinking bifunctionality, follow by peroxidase-mediated phenol coupling for hydrogel-siRNA formation. (b) A table showing various formulations used for the synthesis of gelatin-tyramine (Gtn-Tyr) precursors, resulting in an increasing percentage of conjugated tyramine and zeta potential. (c) A graph showing a linear relationship between the increasing amount of conjugated Tyr with phenol group and zeta potential. (d) Gtn-Tyr precursor displaying ease of injectability through a 32G Hamilton syringe, with the hydrogel formed displaying increasing opacity with increasing zeta potential.

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