Figure 5 | Scientific Reports

Figure 5

From: Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery

Figure 5

Live imaging of operated tissues in a rabbit model of glaucoma filtration surgery with insertion of a 24-gauge cannula. (a–c) Slit-lamp microscopy of the week 4 postoperative tissues treated with MMC, or hydrogel incorporated with scrambled or SPARC siRNAs. While blebs were no longer visible in all the MMC or siScramble-hydrogel treated tissues, 4 of 5 siSPARC-hydrogel treated tissues maintained visible blebs at week 4. (d–l) In vivo confocal images of the week 4 operated area. *, microcysts; red arrowheads, large vasculature; red arrows, fine vasculature.

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