Table 3 Stratified analysis of the cDDD for bisphosphonate and non-bisphosphonate users.

From: Primary Sjogren syndrome increases the risk of bisphosphonate-related osteonecrosis of the jaw

Case 1: bisphosphonate users

pSS

Bisphosphonate users cDDD < 224

Bisphosphonate users cDDD ≥ 224

ADJ. HR

95% CI

ADJ. HR

95% CI

No (Ref.)

1.000

 

1.000

 

Yes

2.407*

(1.412–7.790)

2.143*

(1.046–4.393)

Case 2: Non-bisphosphonate users

pSS

Non-bisphosphonate users cDDD < 224

Non-bisphosphonate users cDDD ≥ 224

ADJ. HR

95% CI

ADJ. HR

95% CI

No (ref.)

1.000

 

1.000

 

Yes

0.447

(0.128–1.562)

0.549

(0.121–2.493)

  1. (1) *0.01 ≤ p < 0.05, **0.0001 ≤ p < 0.01, ***p < 0.0001. (2) ADJ. HR was adjusted by sex, comorbidities, and age at the initiation of bisphosphonate use.
  2. cDDD cumulative dose with defined daily dose, 95% CI 95% confidence interval, ADJ. HR adjusted hazard ratio, Ref reference.