Figure 1

Fox family evolution in Metazoa reveals 27 Fox genes in Schmidtea mediterranea divided in 12 families. (a) pipeline annotate Fox genes. (b) The ML phylogenetic trees based on FKH. Number of genes per family in Schmidtea mediterranea is indicated inside a square next to each family. At nodes, values for the approximate Bayes (square) and Likelihood (circle) ratio test are shown. Colour indicates % of confidence. Family tree branches were collapsed at the base of the common node. One gene was unclassified in any family (UC). Dashed line divides Clade I and Clade II Fox genes. (c) For each node-sharing families, a phylogenetic tree was created using an Amq gene from the opposite clade as out group. Family branches are painted with the same colour as they are represented in the trees. Platyhelminthes genes are coloured light orange. Dark crosses indicate previous characterized genes and dark asterisks indicate new fox characterized in Schmidtea mediterranea (Smed). Aminoacidic sequences used are found in S1 File. Scale indicates expected aminoacidic substitution per site.