Figure 4
Distribution of Fox homologs reveals huge family loss and gene diversification in Platyhelminthes. Coloured boxes indicate the presence of an ortholog based on the phylogenetic analysis. When there were no evidences of ortholog, the box remained white. A number (x Nº) inside a box indicates paralogs per family and species. Families are divided in Clade I and II. Number of genes and number of families per species are indicated. Species were classified into Platyhelminthes and Tricladida phylogeny accordingly to28 and51, respectively. Light orange indicates Platyhelminthes species within turquoise lines indicate Tricladida species; grey box indicates Dugesiidae family. Species belonging to the Tricladida order show different losses, gains and specialization events. Gains (+) and losses (−) of genes are indicated. Specifically, many families were lost in Platyhelminthes (red dashed polygon). FoxA(P) and FoxN(P) origin seems to predate Proseriata and Tricladida order, respectively.
