Table 2 Association analysis and univariate analysis for logarithm 10 levels of IL-8 among colorectal cancer patients.

From: A prognostic model for colorectal cancer based on CEA and a 48-multiplex serum biomarker panel

Association analyses (Mann–Whitney U or Kruskall–Wallis test)

Univariate hazard ratio for disease-specific survival3

 

Median value (pg/ml)

IQR

p value1

 

HR

95% CI

p value4

Gender

Female

43

32–64

0.802

 

1.67

0.96–2.9

0.067

Male

46

33–60

  

2.39

1.42–4.02

0.001

Age

≤ 67

46

35–63

0.221

 

1.86

1.05–3.28

0.033

> 67

42

32–59

  

2.37

1.42–3.95

0.001

Stage

Stage groups

I

37

28–47

< 0.0012

I–II

1.02

0.34–3.11

0.968

II

43

35–57

 

III–IV

1.67

1.11–2.53

0.015

III

40

31–61

     

IV

60

45–110

     

Histology

Non-mucinous

43

33–60

0.800

 

1.85

1.24–2.75

0.003

Mucinous

45

31–76

  

7.76

1.57–38.3

0.012

Side

Right

49.46

37–68

0.005

 

2.34

0.99–5.52

0.052

Left

41.62

31–58

  

2.29

1.48–3.55

< 0.001

Location

Colon

49

35–66

0.005

 

2.19

1.23–3.88

0.008

Rectum

41

31–57

  

2.23

1.31–3.80

0.003

  1. IQR interquartile range, HR hazard ratio, 95% CI 95% confidence interval.
  2. 1p value for the Mann–Whitney U test.
  3. 2p value for the Kruskall-Wallis test.
  4. 3IL-8 dichotomized using the reciever operating curve's maximal Yonden value.
  5. 4p value for the log-rank test.
  6. p-values 0.050 or less are bolded.