Figure 6 | Scientific Reports

Figure 6

From: Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines

Figure 6

Fluoxetine and sertraline marginally increase glucose uptake in SK-OV-3 cells. Bar graphs depict relative cellular glucose uptake assessed by 18F-FDG incorporation of MCF-10A (a), MCF-7 (b) and MDA-MB-231 (c) breast cancer as well as SK-OV-3 (d) NIH:OVCAR-3 (e) and SK-MSC-hyb1 (f) ovarian cancer cells in response to stimulation with 1 µM fluoxetine (Fluo), sertraline (Sert), citalopram (Cita), or 5-HT relative to DMSO-treated control cells (Ctrl) for 72 h. Data, derived from n = 3 (b and e), n = 4 (a and c) or n = 5 (d and e) independent cell passages performed in duplicates, are depicted as means ± SEM. P-values were computed by one-way ANOVA followed by Dunnett’s multiple comparison test; **P < 0.01.

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