Figure 1 | Scientific Reports

Figure 1

From: Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity

Figure 1

Administration of cilastatin suppressed cisplatin-induced kidney injury. (A) BALB/cA mice were administered cisplatin i.p. at a dose of 3 mg/kg or 6 mg/kg on days 0, 3 and 6. Mice that received 6 mg/kg cisplatin were treated s.c. with cilastatin (100 mg/kg) from days 0 to 6 or left untreated. Nine days after the first administration of cisplatin, the kidneys were harvested and stained with KIM-1. (B) The expression of KIM-1 was scored to evaluate the percentage of injured tubules. The KIM-1 staining scores were lower in mice treated with cisplatin with cilastatin combination therapy. (C) BUN was measured by enzymatic methods.

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