Figure 3 | Scientific Reports

Figure 3

From: Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity

Figure 3

Influence of cilastatin on the antitumor effects of cisplatin. (A) BALB/cA mice were inoculated s.c. with CT26 tumor cells along the midline of the abdomen. On days 2 and 5, the mice were treated i.p. with cisplatin (4 mg/kg) with or without administration of cilastatin (100 mg/kg) s.c. from days 2 to 8. The resultant skin tumors were measured in 2 perpendicular directions 3 times per week, and the tumor areas (mm2) were recorded. (B) SCID mice were injected s.c. with A549 tumor cells. The mice were administered cisplatin (3 mg/kg) i.p. on days 2, 5 and 8 with or without treatment with cilastatin (100 mg/kg) s.c.

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