Figure 5
From: Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice
Kidney and adipose tissue mRNA expression levels of inflammatory cytokines in each group. (A) Kidney. (B) Adipose tissue. Two-way ANOVA was used to evaluate the individual effects of the presence/absence of PGRN and diet type and their interactions. In the kidney, Ccl2 and Vcam1 mRNA expression levels are significantly associated with both PGRN status and diet type. In contrast to the effect on kidney mRNA expression levels, PGRN status and diet type enhance adipose tissue Ccl2 mRNA expression levels in the WT-HFD group. For the mRNA expression levels of Vcam1 in the kidney and Ccl2 in the adipose tissue, main effects were confirmed for PGRN status and diet type and for an interaction between PGRN status and diet type based on post hoc Tukey’s honestly significant difference test. Data are shown as fold changes compared to the WT-SD group, *p < 0.05 versus WT-HFD, †p < 0.05 versus KO-SD.
