Figure 7
From: Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice
mRNA expression levels of Lrp2 and Grn in cultured mouse PTECs stimulated with TNFα. (A) The mRNA expression levels of Lrp2 and Grn are reduced in a dose-dependent manner in PTECs stimulated with TNFα. Tukey’s honestly significant difference test. *p < 0.05 versus no TNFα stimulation. (B) Effects of PGRN siRNA on megalin expression in PTECs stimulated with 10 ng/mL TNFα. Two-way ANOVA shows significant main effects of PGRN knockdown and TNFα stimulation on the expression of megalin (p < 0.01 and p = 0.04, respectively), without significant interaction (p = 0.64), showing that knocking down PGRN reduces megalin expression.
