Figure 1
From: The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent
TLR8 gene expression is associated with HNSCC patient survival. (A) Shown are Kaplan–Meier survival curves comparing overall survival of HNSCC patients (n = 522) from the TCGA database according to high (n = 91), medium (n = 316) or low (n = 115) TLR8 expression. (B, C): Dot-box plots illustrate the percentage of activated memory CD4+ (B) and CD8+ (C) tumor infiltrating T cells in HNSCC patients with high, medium and low TLR8 expression from (A). Error bars represent standard deviation of the mean. (D–F) Correlation analysis (Pearson’s correlation tests) between TLR8 and CD4 (D), CD8A (E) and ITGAX (F) of all HNSCC patients from (A). **p < 0.01, ***p < 0.001, ****p < 0.0001, n.s.-non-significant (One-way ANOVA, Tukey’s multiple comparison test).
