Table 1 Patient characteristics by TLR8 staining.
From: The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent
TLR8 Score | ||||||
|---|---|---|---|---|---|---|
Characteristics | Total (n) | 3 | 2 | 1 | 0 | p-value |
Number of evaluable subjects: n | 145 | 27 | 46 | 50 | 22 | |
Sex: n (%) | ||||||
Male | 84 | 14 (17) | 29 (35) | 27 (32) | 14 (17) | p = 0.52 |
Female | 61 | 13 (21) | 17 (28) | 23 (38) | 8 (13) | |
Age: average (range) | 62 (19–93) | 63 (20–93) | 58 (19–89) | 64 (37–93) | 61 (35–80) | p = 0.27 |
Male | 58 (31–81) | 57 (31–70) | 57 (40–81) | 60 (37–76) | 60 (37–77) | p = 0.93 |
Female | 66 (19–33) | 70 (20–93) | 61 (19–89) | 69 (37–93) | 64 (35–80) | |
Smoking history: n (%) | ||||||
Active smoker | 57 | 3 (5) | 20 (35) | 24 (42) | 10 (18) | |
Never smoker | 51 | 11 (22) | 15 (29) | 18 (35) | 7 (14) | |
Quit < 10 years | 13 | 6 (46) | 3 (23) | 2 (15) | 2 (15) | p < 0.001 |
Quit > 10 years | 18 | 5 (28) | 5 (28) | 5 (28) | 3 (17) | |
Tobacco chewer | 6 | 2 (33) | 3 (50) | 1 (17) | 0 (0) | |
Tumor site: n (%) | ||||||
Alveolus | 23 | 5 (22) | 6 (26) | 10 (44) | 2 (9) | |
Floor of the mouth | 32 | 2 (6) | 12 (38) | 14 (44) | 4 (12.5) | p = 0.004 |
Oral tongue | 55 | 13 (24) | 17 (31) | 16 (29) | 9 (16) | |
Other | 35 | 7 (20) | 11 (31) | 10 (29) | 7 (20) | |
T Stage: n (%) | ||||||
T1 | 43 | 7 (16) | 14 (33) | 14 (33) | 8 (19) | |
T2 | 43 | 10 (23) | 13 (30) | 13 (30) | 7 (16) | p = 0.61 |
T3/T4 | 59 | 10 (17) | 19 (32) | 23 (39) | 7 (12) | |
N Stage: n (%) | ||||||
N0 | 74 | 17 (23) | 23 (31) | 24 (32) | 10 (14) | |
N1/2a | 29 | 5 (17) | 7 (24) | 8 (28) | 9 (31) | p < 0.001 |
N2b/2c/3 | 42 | 5 (12) | 16 (38) | 18 (43) | 3 (7) | |
Differentiation: n (%) | ||||||
Well | 17 | 2 (11) | 6 (36) | 7 (41) | 2 (12) | |
Moderate | 91 | 16 (18) | 29 (32) | 33 (36) | 13 (14) | p = 0.17 |
Poor | 37 | 9 (24) | 11 (30) | 10 (27) | 7 (19) | |
Perineural invasion: n (%) | ||||||
Yes | 73 | 11 (15) | 23 (32) | 25 (34) | 14 (19) | p = 0.32 |
No | 72 | 16 (22) | 23 (32) | 25 (35) | 8 (11) | |
Lymphovascular invasion: n (%) | ||||||
Yes | 54 | 6 (11) | 20 (37) | 20 (37) | 8 (15) | p = 0.14 |
No | 91 | 21 (23) | 26 (29) | 30 (33) | 14 (17) | |
Bone invasion: n (%) | ||||||
Yes | 44 | 6 (14) | 17 (39) | 16 (37) | 5 (11) | p = 0.23 |
No | 101 | 21 (21) | 29 (29) | 34 (34) | 17 (17) | |
Radiotherapy: n (%) | ||||||
Yes | 81 | 13 (16) | 25 (31) | 29 (36) | 14 (17) | p = 0.59 |
No | 64 | 14 (21) | 21 (33) | 20 (31) | 8 (13) | |
Chemotherapy: n (%) | ||||||
Yes | 23 | 1 (4) | 6 (26) | 9 (39) | 7 (30) | p = 0.0002 |
No | 122 | 26 (21) | 40 (33) | 41 (34) | 15 (12) | |
