Table 2 Bio-humoral data of the study population and of groups defined by TG/HDL-C quartiles. [Continuous variables are presented as mean ± standard deviation; # = LDL-C was not calculated in 3 patients with TG > 400 mg/dL in the IV quartile].

From: Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina

Biomarkers

Study population n = 355

Quartile I < 1.305 n = 89

Quartile II 1.305–2.095 n = 89

Quartile III 2.129–3.384 n = 88

Quartile IV > 3.384 n = 89

P value  for trend

Lipid metabolism

Total cholesterol, mg/dL

180 ± 47

184 ± 45

182 ± 50

172 ± 47

180 ± 47

ns

 LDL-C, mg/dL#

104 ± 38

106 ± 36

108 ± 39

103 ± 39

99 ± 39

ns

 HDL-C, mg/dL

52 ± 17

66 ± 17

56 ± 14

46 ± 11

39 ± 9

 < 0.0001

 Total/HDL-C

3.7 ± 1.1

2.84 ± 0.58

3.30 ± 0.56

3.87 ± 1.01

4.67 ± 1.17

 < 0.0001

 Remnant-C

24 ± 15

12 ± 4

19 ± 5

24 ± 7

42 ± 17

 < 0.0001

 Triglicerides, mg/dL

123 ± 77

61 ± 17

92 ± 23

119 ± 31

219 ± 89

 < 0.0001

 Triglicerides/HDL-C

2.78 ± 2.37

0.96 ± 0.25

1.67 ± 0.23

2.63 ± 0.41

10.05 ± 0.46

 < 0.0001

 Apo A1, mg/dL

143 ± 32

158 ± 35

149 ± 31

136 ± 26

128 ± 26

 < 0.0001

 Apo B, mg/dL

86 ± 27

80 ± 22

85 ± 25

84 ± 29

96 ± 29

0.0027

 Apo B/Apo A1

0.62 ± 0.22

0.54 ± 0.26

0.57 ± 0.12

0.62 ± 0.16

0.77 ± 0.24

 < 0.0001

 Lipoprotein (a), mg/dL

21.9 ± 24.3

23.4 ± 27.0

23.8 ± 22.7

23.3 ± 25.5

16.9 ± 21.3

ns

 PCSK9, ng/mL

223 ± 136

247 ± 130

220 ± 123

226 ± 129

200 ± 156

0.0125

Glucose metabolism

 FPG, mg/dL

111 ± 36

103 ± 20

109 ± 37

116 ± 42

117 ± 38

0.0209

 TyG index

8.65 ± 0.63

8.00 ± 0.35

8.46 ± 0.37

8.77 ± 0.41

9.35 ± 0.46

 < 0.0001

 Insulin, mUI/mL

11.3 ± 11.0

7.2 ± 6.3

9.9 ± 8.9

12.4 ± 11.8

15.5 ± 13.7

 < 0.0001

 HOMA-IR index

3.3 ± 4.0

1.9 ± 1.9

2.9 ± 3.5

3.8 ± 4.7

4.7 ± 4.7

 < 0.0001

Hepatic function

      

 AST, IU/L

24 ± 9

25 ± 9

24 ± 9

24 ± 9

25 ± 10

ns

 ALT, IU/L

21 ± 11

19 ± 11

19 ± 9

22 ± 13

22 ± 11

0.0117

 ALP, IU/L

51 ± 18

50 ± 18

50 ± 18

52 ± 18

52 ± 18

ns

 GGT, IU/L

39 ± 30

36 ± 43

35 ± 30

37 ± 15

47 ± 20

 < 0.0001

Inflammation

 hs-CRP, mg/dL

0.41 ± 1.26

0.48 ± 2.24

0.42 ± 0.83

0.44 ± 0.68

0.32 ± 0.42

ns

 Interleukin 6, ng/L

1.35 ± 2.63

1.33 ± 3.81

1.21 ± 1.32

1.55 ± 2.37

1.29 ± 2.46

ns

Adipocytokines

 Leptin, ng/mL

10.4 ± 11.0

10.5 ± 9.1

12.0 ± 14.4

9.1 ± 9.1

10.1 ± 10.4

ns

Adiponectin, mg/mL

9.6 ± 6.5

13.8 ± 8.7

9.0 ± 5.1

9.0 ± 5.4

6.8 ± 3.8

 < 0.0001

Myocardial Damage

 hs-cTnT, ng/L

8.0 ± 6.2

7.0 ± 5.7

7.4 ± 6.3

9.0 ± 6.8

8.5 ± 6.0

0.0043

 hs-cTnI, ng/L

52.5 ± 233.6

23.4 ± 154.6

42. 6 ± 300.5

46.8 ± 158.5

97.2 ± 278.3

 < 0.0001

 NT-proBNP, ng/L

134.8 ± 223.2

133.9 ± 172.8

104.1 ± 127.2

168.6 ± 325.6

133.0 ± 217.8

ns

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