Figure 1 | Scientific Reports

Figure 1

From: Altered protein O-GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast cells

Figure 1

The top ten canonical pathways identified using ingenuity pathway analysis (IPA) of placental O-GlcNAcylated proteins with a > twofold change in abundance between control and maternal disease. Fold change was calculated as a change in abundance of placental proteins from mothers with T1D compared to mothers with a normal BMI (20–25) (A) or mothers with T2D compared to mothers with an obese BMI (> 30) (B). Pathways were ranked on a combination of the ratio and p-value. Ratio was calculated by the number of proteins altered (up—red; down—green) in the dataset compared to the total number of known proteins (indicated to the right hand side) within the canonical pathway. The p-value (orange line) indicates the significance of datasets association with the canonical pathway, as calculated by a Right-sided Fishers exact test using IPA.

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