Figure 3
From: Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine
Effect of three crude drug extracts on Rat-1 fibroblasts expressing Per2-luc and lung explants from Per2::Luciferase knockin mice. (A) Luminescent traces (left) and dose-dependent effects on the circadian period (middle) and phase (right) in Rat-1 cells. Values are averages of three replicates ± SD and were analyzed using one-way ANOVA, followed by Dunnett’s multiple comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001, **** p < 0.0001). (B) Effects of the extracts of Artemisiae Capillaris Flos (top), Perillae Herba (middle), and Allii Chinense Bulbus (bottom) on lung explants of Per2::Luciferase knockin mice. Luminescent traces (left) and effects on period (middle) and phase (right). Values are averages of three replicates ± SD and were analyzed using Student's t-test. (*p < 0.05).
