Table 3 Comparison between means and standard deviation of Doppler indexes in the ophthalmic and middle cerebral arteries of smoking and non-smoking women.

	Doppler Parameters	Mean	sd	CI	95%	p- value	p- value after MANCOVA	Cohen's d
	Doppler Parameters	Mean	sd	Lower Bound	Upper Bound	p- value	p- value after MANCOVA	Cohen's d
SG	RI OA	0,76	0,06	0,75	0,77	ns
CG	RI OA	0,77	0,05	0,76	0,77
SG	PI OA	1,62	0,36	1,52	1,71	0.008	smoke: < 0.001	0.547
CG	PI OA	1,84	0,40	1,78	1,92		age: < 0.001 ocp: 0.74
SG	PVS OA cm/s	26,59	6,25	25,05	28,12	ns
CG	PVS OA cm/s	28,83	5,80	27,83	29,84
SG	P2 AO cm/s	20,47	5,23	19,03	21,70	ns
CG	P2OA cm/s	19,61	6,29	18,26	20,02
SG	PR OA	0,77	0,15	0,73	0,80	0.001	smoke: < 0,001	0.777
CG	PR OA	0,66	0,13	0,63	0,68		age: < 0.001 ocp: 0.227
SG	EDV AO cm/s	6,32	2,00	5,81	6,77	ns
CG	EDV AO cm/s	6,59	1,96	6,32	6,94
SG	MV OA cm/s	12,87	3,22	11,95	13,58	ns
CG	MV AO cm/s	12,34	3,54	11,96	13,02
SG	RI MCA	0,60	0,06	0,58	0,61	0,001	smoke: 0.003	− 0.429
CG	RI MCA	0,57	0,06	0,56	0,58		age:0.740 ocp: 0.217
SG	PI MCA	0,94	0,18	0,90	0,97	0,001	smoke: 0.006	− 0.397
CG	PI MCA	0,87	0,13	0,85	0,90		age:0.666 ocp: 0.107
SG	PVS MCA cm/s	78,62	19,19	74,56	82,68	ns
CG	PVS MCA cm/s	79,03	15,43	77,43	82,77
SG	EDV MCA cm/s	31,08	10,03	28,90	33,24	0,039	smoke: 0.041	0.291
CG	EDV MCA cm/s	34,64	8,91	32,35	35,21		age: 0.336 ocp:0.076
SG	MV MCA cm/s	51,04	13,50	48,15	53,91	ns
CG	MV MCA cm/s	52,90	11,74	50,91	54,70

OA Ophthalmic Artery, MCA Middle Cerebral Artery, MV mean velocity, RI Resistance Index, PI Pulsatility Index, PVS Peak of Velocity Systolic, P2 second peak of velocity, PR peak ratio, EDV End Diastolic Velocity, SG study group, CG control group, cm/s centimeter/second, ocp oral contraceptive, sd standard deviation, ns non significant.

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