Figure 8
Non-polar interactions made by aromatic residues compensate for structural inaccuracies in H3 redesign. The H3 loop conformations are rendered as tubes colored white for the crystal structure and orange for the modeled structure corresponding to the lowest Talaris energy. Aromatic residues from each H3 loop boxed in the BRMSD/SASA diagrams (as per Fig. 6) are displayed with capped sticks. A molecular lipophilicity surface of the VEGF antigen is rendered for the crystal structure determined for each design (Green = Lipophilic, Purple = Hydrophilic, White = Neutral, Created in MOE).
