Figure 2
From: Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling
Cardiomyocyte expression of miRNA-7 leads to age-based cardiac dilation (a), M-mode echocardiography performed on NTg and Tg mice at 3, 6, 12 and 18 months (n = 12). (b), Cardiac functional parameters measured from echocardiography on NTg and Tg mice; Left panel: LVEDD (left ventricular end-diastolic dimension); Middle panel LVESD (left ventricular end-systolic dimension); Right panel: % fractional shortening (%FS) as measure of cardiac function. *p < 0.01 vs. 3 month NTg and Tg; #p < 0.05 vs. 3 month NTg and Tg. (c) Immunoblotting for ERBB2 in the total cardiac lysates from NTg and Tg mice. Immunoblotting for GAPDH was performed for loading control (n = 8). Summary data represented in the bar graph (right panel). *p < 0.001 vs. NTg. (d), Immunoblotting for ERBB2 and EGFR in isolated adult cardiomyocytes from NTg and Tg mice. Immunoblotting for GAPDH was performed as loading control (n = 4–5). Summary data represented in the bar graph (right panel). *p < 0.0005 vs. NTg.
