Figure 3
From: Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling
Cardiomyocyte expression of miRNA-7 exacerbates cardiac dysfunction and failure following pressure overload by transverse aortic constriction (TAC) (a), Kaplan–Meier survival curves for 12 months old NTg and Tg mice subjected to TAC (n = 8). (b), Real time PCR analysis for miRNA-7 expression from cardiac tissue of NTg mice following Sham, 1 or 2 weeks of TAC. *p < 0.001 vs. SHAM; #p < 0.01 vs. 1 week TAC (n = 8). (c), Heart weight to body weight (HW/BW) ratio of NTg and Tg following two weeks of TAC in 3 months old mice (n = 11).*p < 0.05 vs. SHAM. (d–g) Cardiac functional parameters of NTg and Tg mice measured by echocardiography following 2 weeks of TAC (n = 11); LVEDD (left ventricular end-diastolic dimension) (d), LVESD (left ventricular end-systolic dimension) (e), percent fractional shortening (%FS) (f), percent ejection fraction (%EF) (g). *p < 0.005 vs. Sham (NTg or Tg) and pre-TAC (NTg or Tg) (n = 11).
