Figure 5
From: Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling
Cardiac proteomics and network analysis of miRNA-7 targets in NTg and Tg hearts (a), Gene ontology (GO) functional analysis using the significantly altered proteins in the Tg versus NTg from cardiac proteomics shows unique molecular functional changes in the Tg wherein phagocytosis, actin remodeling and acute inflammation are upregulated (red color coding). While, mitochondrial structure and function are downregulated (blue color coding) (https://apps.cytoscape.org/apps/cluego). (b), GO cellular component analysis shows upregulation of proteosomal components (red color) while, majority of the pathways are associated with downregulation of mitochondrial structural components. (c), Venn diagram showing an overlap of predicted targets (from prediction databases TargetScan and miRDB) and truly altered proteins identified in the cardiac proteomic studies from NTg and Tg hearts. Seven common proteins identified are shown in right that are all downregulated in the miRNA-7 Tg mice compared to NTg.
