Table 1 Age-dependent Echocardiography and Morphometric parameters for NTg and miRNA-7 Tg mice.
From: Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling
| Â | 3 Months (12) | 6Â months (12) | 12Â months (12) | 18Â months (12) | ||||
|---|---|---|---|---|---|---|---|---|
NTg | Tg | NTg | Tg | NTg | Tg | NTg | Tg | |
Morphometry | ||||||||
HW (mg) | 120 ± 2.2 | 140 ± 2.1* | 145 ± 2.5 | 168 ± 4.5* | 180 ± 2.6 | 185 ± 2.5 | 191 ± 2.3 | 179 ± 2.3* |
BW (g) | 25.1 ± 0.4 | 25.7 ± 0.52 | 30.5 ± 0.57 | 30.6 ± 0.95 | 34.3 ± 0.53 | 34.7 ± 0.59 | 38.3 ± 0.48 | 39.0 ± 0.42 |
HW/BW (mg/g) | 4.78 ± 0.09 | 5.47 ± 0.15* | 4.78 ± 0.16 | 5.52 ± 0.13* | 5.25 ± 0.12 | 5.35 ± 0.10 | 5.01 ± 0.08 | 4.60 ± 0.07* |
Echocardiography | ||||||||
LVEDD (mm) | 3.34 ± 0.06 | 3.44 ± 0.06 | 3.45 ± 0.05 | 3.53 ± 0.06 | 3.52 ± 0.06 | 3.90 ± 0.73*# | 3.88 ± 0.06 | 4.10 ± 0.06*# |
LVESD (mm) | 1.89 ± 0.03 | 1.94 ± 0.05 | 2.07 ± 0.03 | 2.12 ± 0.06 | 2.17 ± 0.07 | 2.70 ± 0.07*# | 2.63 ± 0.08 | 3.11 ± 0.07*# |
PW (mm) | 0.65 ± 0.04 | 0.65 ± 0.05 | 0.71 ± 0.04 | 0.66 ± 0.05 | 0.78 ± 0.06 | 0.50 ± 0.05*# | 0.66 ± 0.04 | 0.44 ± 0.04*# |
AW (mm) | 0.83 ± 0.03 | 0.86 ± 0.04 | 0.87 ± 0.03 | 0.86 ± 0.05 | 0.94 ± 0.06 | 0.71 ± 0.06*# | 0.89 ± 0.06 | 0.59 ± 0.06*# |
%FS | 43.4 ± 1.57 | 43.2 ± 1.30 | 40.4 ± 1.62 | 39.9 ± 1.37 | 38.3 ± 1.69 | 30.7 ± 1.50*# | 32.0 ± 1.59 | 24.1 ± 1.54*# |
%EF | 75.7 ± 1.45 | 75.5 ± 1.32 | 71.4 ± 1.69 | 71.2 ± 1.52 | 69.2 ± 1.54 | 58.1 ± 1.47*# | 61.5 ± 1.71 | 48.4 ± 1.78*# |
