Table 2 Morphometric and echocardiographic parameter for NTg and miRNA-7 Tg mice with TAC (2 weeks).
From: Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling
Morphometry | NTg | Tg (miRNA-7) | ||||||
|---|---|---|---|---|---|---|---|---|
Sham | TAC | Sham | TAC | |||||
n = 10 | n = 11 | n = 11 | n = 11 | |||||
Heart weight (HW, mg) | 125 ± 4.77 | 152 ± 6.98* | 143 ± 5.09* | 177.2 ± 10.2*# | ||||
Body weight (BW, g) | 26.3 ± 0.95 | 25.9 ± 0.80 | 26.6 ± 0.86 | 24.6 ± 0.6 | ||||
HW/BW (mg/g) | 4.74 ± 0.07 | 5.87 ± 0.23* | 5.39 ± 0.10* | 7.25 ± 0.48*# | ||||
Echocardiography | n = 10 | n = 11 | n = 11 | n = 11 | ||||
|---|---|---|---|---|---|---|---|---|
Pre | Post | Pre | Post | Pre | Post | Pre | Post | |
LVEDD (mm) | 3.37 ± 0.03 | 3.38 ± 0.07 | 3.36 ± 0.03 | 3.60 ± 0.05* | 3.49 ± 0.06 | 3.50 ± 0.07 | 3.49 ± 0.05 | 4.11 ± 0.09*# |
LVESD (mm) | 1.90 ± 0.04 | 1.91 ± 0.04 | 1.90 ± 0.05 | 2.02 ± 0.06* | 1.97 ± 0.04 | 1.97 ± 0.06 | 1.98 ± 0.06 | 3.01 ± 0.08*# |
PW (mm) | 0.62 ± 0.02 | 0.64 ± 0.03 | 0.62 ± 0.01 | 0.80 ± 0.03* | 0.63 ± 0.02 | 0.63 ± 0.02 | 0.62 ± 0.01 | 0.37 ± 0.03*# |
AW (mm) | 0.83 ± 0.03 | 0.85 ± 0.03 | 0.84 ± 0.05 | 1.11 ± 0.07* | 0.88 ± 0.03 | 0.88 ± 0.03 | 0.87 ± 0.03 | 0.50 ± 0.03*# |
FS (%) | 43.6 ± 1.25 | 43.5 ± 2.12 | 43.6 ± 1.55 | 43.7 ± 1.02 | 43.4 ± 0.82 | 43.5 ± 1.25 | 43.6 ± 1.35 | 26.7 ± 1.35*# |
EF(%) | 75.9 ± 1.36 | 75.8 ± 2.24 | 75.9 ± 1.68 | 75.8 ± 1.17 | 75.6 ± 0.89 | 75.7 ± 1.38 | 75.2 ± 1.55 | 52.6 ± 2.12*# |
