Table 5 Cox hazard analysis of overall survival in NHLs (n = 138).

From: Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma

Variables

Cut off

Univariate analysis

Multivariate analysis

HR

95% CI

P value

HR

95% CI

P value

Age

60

4.4

1.82–10.49

0.001*

3.5

1.42–8.46

0.006*

Gender

Male/female

0.6

0.3–1.09

0.08

   

CS

Limited/advanced

1.4

0.68–2.75

0.371

   

HGB level

Normal/decreased

2.8

1.46–5.33

0.002*

1.9

0.99–3.37

0.05*

Serum LDH

Normal/increased

2.5

1.32–4.91

0.005*

1.6

0.84–3.22

0.15

BMI

No/yes

1.4

0.98–2.03

0.06

   

Extranodal involvement

No/yes

1.2

0.63–2.22

0.613

   

Cytogenetic abnormality

No/yes

0.9

0.58–1.39

0.629

   

Ki-67 expression

70% low/high

0.7

0.25–2.06

0.605

   

LAT1 expression

Low/high

2.9

1.35–6.41

0.006*

2.4

1.10–5.23

0.028*

  1. BMI, bone marrow involvement; CI, confidence interval; CS, cancer stage; HGB level, hemoglobin level; HR, hazard ratio; serum LDH, serum lactate dehydrogenase.
  2. *P-value < 0.05 indicates a significant difference.
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