Table 3 Estimated equilibrium concentrations of main small ions (in mOsm/L H2O) in human interstitial fluid (assumed protein equivalent: − 4.3 mEq/L)

From: Calculation of the Gibbs–Donnan factors for multi-ion solutions with non-permeating charge on both sides of a permselective membrane

Ion

Estimated equilibrium concentrations: interstitial fluid

Estimated equilibrium concentrations: protein-free fluid

Estimated Gibbs–Donnan factor

Na+

138.3

136.3

0.99

K+

4.1

4.0

0.99

Ca2+

1.2

1.2

0.97

Mg2+

0.8

0.7

0.97

Cl

110.9

112.5

1.02

HCO3

24.7

25.0

1.02

Lactate

1.2

1.3

1.02

SO42−

0.5

0.5

1.03

HPO42−

2.1

2.2

1.03