Table 4 Training, validation, and test splits information for the segmentation and classification models.

From: Uncovering associations between data-driven learned qMRI biomarkers and chronic pain

Task

Model

Training (cases)

Validation (cases)

Test (cases)

Cases ratio

Average time points per patient

Timepoint distribution (number of timepoints per number of patients)

Average age (mean ± SD)

Average KL (mean ± SD)

Sex distribution (male/female)

Total WOMAC pain scores (mean ± SD)

χ2 test correlation (sex) (p-values)

MANOVA one-way correlation (age|BMI) (p-values)

Segmentation

Bone

57 (29)

15 (8)

30 (16)

0.520

1.01

1:100

58.4 ± 8.19

0.6 ± 1.06

49/53

2.4 ± 2.90

0.745

0.413

2:1

Cartilage

118 (114)

28 (28)

28 (28)

0.977

2.0

2:87

61.6 ± 9.93

2.3 ± 0.94

90/84

4.3 ± 3.80

0.156

1 × 10–4

Classification

OA

12,634 (5402)

2558 (1111)

5926 (2530)

0.428

4.78

1:179

63.2 ± 9.17

1.3 ± 1.21

9005/12,113

2.1 ± 2.95

0.121

0.190

2:396

3:419

4:601

5:1367

6:527

7:927

Chronic pain

4029 (1324)

1257 (411)

2151 (713)

0.329

2.42

1:1103

63.9 ± 9.38

1.2 ± 1.22

3510/3927

1.5 ± 2.77

0.179

0.0848

2:771

3:509

4:345

5:192

6:104

7:43

  1. Demographic factors were controlled by testing for statistical independence across the splits using a Pearson’s chi-squared test (χ2) for the categorical sex variable and a one-way Multivariate Analysis of Variance (MANOVA) for the joint effect of age and BMI.
  2. Bold p-values are significant (p-value < 0.05).