Figure 4 | Scientific Reports

Figure 4

From: ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

Figure 4

Hypothetical model. Through interacting with RIPK2, ASK1 negatively regulates the NOD-RIPK2 pathway and inflammatory cytokine production in brown adipocytes. Along with the maturation-enhancing effect of ASK1 via the PKA-ASK1-p38 axis under β3-adrenergic receptor stimulation19, this regulation would contribute to maintaining brown adipocyte function under inflammation.

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