Table 2 Hazard ratios for diabetes by number of cumulative days antibiotics prescribed.

From: Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans

 

Antibiotics non-user

Number of cumulative days antibiotics prescribed

p for trend

1–29

30–89

≥ 90

Events, N

1586

7047

3989

1144

 

Person-years, 104

23

103

53

13

 

aHR (95% CI)

Model 1

1.00 (ref.)

1.00 (0.94 1.05)

1.07 (1.01 1.13)

1.20 (1.11 1.30)

< 0.001

Model 2

1.00 (ref.)

1.01 (0.96 1.07)

1.09 (1.03 1.16)

1.24 (1.15 1.34)

< 0.001

Model 3

1.00 (ref.)

0.98 (0.93 1.04)

1.04 (0.97 1.11)

1.16 (1.07 1.26)

< 0.001

aHR (95% CI)

Model 1

1.01 (0.95 1.06)

1.00 (ref.)

1.07 (1.03 1.11)

1.21 (1.13 1.29)

< 0.001

Model 2

0.99 (0.94 1.05)

1.00 (ref.)

1.08 (1.04 1.13)

1.23 (1.16 1.31)

< 0.001

Model 3

1.02 (0.96 1.08)

1.00 (ref.)

1.06 (1.02 1.10)

1.18 (1.11 1.26)

< 0.001

  1. aHR adjusted hazard ratio, CI confidence interval, ref. reference.
  2. Model 1 Adjusted for age, sex, and body mass index.
  3. Model 2 Adjusted for Model 1 plus smoking status, days with alcohol drinking per week, physical activity, household income, and residence.
  4. Model 3 Adjusted for Model 2 plus family history of diabetes, Charlson comorbidity index, fasting blood sugar, total cholesterol, and acid suppressants use.
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