Table 1 Characteristics of patients receiving unrelated CBT.

Number of patients

65

Median age in years at transplantation (range)

5 years old (27 days-15 years old)

Male: Female

39 (60%): 26 (40%)

Diagnosis

Transfusion-dependent thalassemia

26

40.0%

Severe aplastic anemia

5

7.7%

Fanconi anemia

3

4.6%

ALL

7

10.8%

AML

3

4.6%

CML

1

1.5%

Inheritable disease

14

21.5%

(chronic primary granulomatous disease, X-linked severe combined immunodeficiency, Wiskott-Aldrich Syndrome, malignant osteopetrosis)

Tumor disease

6

9.2%

(neuroblastoma, retroperitoneal neuroblastoma, malignant tumor)

Matching at antigen-level for HLA-A and -B and allele-level for HLA-DRB1

Fully matched

15

23.1%

One mismatch

27

41.5%

Two mismatches

23

35.4%

ABO compatibility

Full match

31

47.7%

Minor mismatch

18

27.7%

Major mismatch

16

24.6%

Overall survival

50

76.9%

GVHD

Non-GVHD

11

16.9%

Grade 1–2

27

41.5%

Grade 3–4

14

21.5%

Chronic

13

20.0%

CMV infection/reactivation

Negative

45

69%

Positive

20

31%