Figure 6

Cystometry and urinary parameters showing time-course of recovery of external urethral sphincter (EUS) and bladder activity after vaginal distension (VD) and sham VD (SH-VD). (A) Representative electromyograms (EMGs) with tonic and bursting activity of the EUS, and bladder contractions at voiding during cystometry in SH-VD rats (upper trace), and following 0 and 7 days after VD. The black arrow indicates the presence of intraluminal pressure high-frequency oscillations. (B) Representative EMGs of the EUS with phasic pattern activity during urine expulsion at voiding while performing simultaneous cystometry in SH-VD rats (upper trace in A), and immediately after VD, and at day 7 following VD. (C) Graphs depicting cystometric parameters from SH-VD and VD rats from immediate to 3, 6–8 and 9–11 days post-VD. Values are mean ± standard error of the mean. * (p < 0.05), ** (p < 0.01) and *** (p < 0.001) indicate significant differences for 0–3 days after VD vs. SH-VD and VD on days 6–8 and 9–11. ++ (p < 0.01) indicates significant differences at 6–8 days after VD vs. SH-VD rats (One Way ANOVA).